Sourav Roy, Ph.D., earned his bachelor’s degree with honors in Zoology from the University of Calcutta in India. Later, he earned a master of science in Zoology with specialization in Cytology and Genetics and a post-graduate diploma in Information Technology and Management from India. He went on to earn a master’s degree in Bioinformatics from Indiana University Bloomington before joining the University of California Riverside (UCR) for his Ph.D. in Genetics, Genomics and Bioinformatics. Roy received the Dean’s Distinguished Fellowship Award for his pre-doctoral studies. After completion of his Ph.D. in 2011, he worked as a postdoctoral scholar for a little over a year before accepting the position of an assistant professional researcher in the Department of Entomology at UCR. Roy joined the Department of Biological Sciences at St. Mary’s University in August 2018.
Roy is a broadly trained biologist with more than 10 years of research experience in the field of genomics and bioinformatics. He has been studying regulatory and evolutionary genomics using molecular biology techniques combined with genomics, transcriptomics and bioinformatics in plant pathogens, insect vectors and humans. He was successful in developing computational methods for predicting cis-regulatory elements and miRNA targets in different organisms during his pre- and post-doctoral studies. To date, he has co-authored a book chapter and 23 peer-reviewed publications in highly reputed journals.
Roy has been working with the arthropod vector for Dengue, Zika and Yellow fever – the Aedes aegypti mosquito. His current projects are related to the identification and validation of regulatory elements and microRNA targets involved in blood digestion and reproductive development of female mosquitoes. These projects involve analysis of high throughput and/or next-generation sequencing data using bioinformatics tools and molecular techniques like cloning, RNA-interference (RNAi) and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The broader objective of these projects is to have a better understanding of the regulatory mechanisms and the role of hormones in the differential expression of genes during the reproductive development in female mosquitoes. The acquired knowledge can thereby pave the way for new and improved disease control strategies. Roy is the Co-PI for a R01 grant awarded by National Institutes of Health for studying the “Molecular Basis of Ecdysteroid Action in the Mosquito.”
Roy S*, Saha TT*, Zou Z and Raikhel AS. Regulatory pathways controlling female insect reproduction. Annual Reviews of Entomology, 2018: 63: 489 – 511.
Woods-Burnham L, Basu A, Cajigas-Du Ross CK, Love A, Yates C, De Leon M, Roy S, Casiano CA. Ancestry determination of the human PCa cell line, 22Rv1. The Prostate. 2017: 77: 1601–1608.
Roy S, Smykal V, Johnson L, Saha TT, Zou Z, Raikhel AS. Regulation of reproductive processes in female mosquitoes. Adv. Insect Physiol. 2016: Vol 51. Elsevier.
Roy S*, Saha TT*, Johnson L, Zhao B, Ha J, Backman, TW, Girke T, White KP, Zou Z, Raikhel AS. Regulation of Gene Expression Patterns in Mosquito Reproduction. PLoS Genet. 2015: 11(8): e1005450.
Lucas KJ, Roy S, Ha J, Gervaise AL, Kokoza VA, Raikhel AS. MicroRNA-8 targets the Wingless signaling pathway in the female mosquito fat body to regulate reproductive processes. PNAS. 2015 Feb: 112(5):1440-5.
Liu S., Lucas K.J., Roy S., Ha J., Raikhel A.S. Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut. PNAS. 2014: 111(40):14460-5.
Zou Z*, Saha TT*, Roy S*, Shin SW, Backman TW, Girke T, White KP, Raikhel AS. Juvenile hormone and its receptor Methoprene-tolerant control mosquito gene expression dynamics. PNAS. 2013: 110(24): E2173-81.
Roy S, Kagda M, Judelson HS. Genome-wide prediction and functional validation of promoter motifs regulating gene expression in spore and infection stages of Phytophthora infestans. PLoS Pathog. 2013: 9(3): e1003182.
Roy S*, Poidevin L*, Jiang T, Judelson HS. Novel core promoter elements in oomycete pathogen Phytophthora infestans and their influence on expression detected by genome-wide analysis. BMC Genomics. 2013: 16:14:106.
Haas BJ, …, Roy S, …, Nusbaum C. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature. 2009: 461(7262): 393-8.
Roy S, Schnell S, Radivojac P. Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map. Comput Biol Chem. 2006: 30(4): 241-8.