• Ph.D., UT Health San Antonio, 2016
  • B.Sc., University of Ulster at Coleraine, 2010


  • Anatomy
  • General Biology for Majors I
  • General Biology for Majors II


Rebekah Mahoney, Ph.D., is Visiting Assistant Professor of Biological Sciences at St. Mary’s University. She joined the University in August 2019.

Mahoney received her Ph.D. in Physiology from UT Health San Antonio in 2016. She came to the United States from Northern Ireland, where she received her Bachelor of Science with honors in Biomedical Sciences from the University of Ulster in Coleraine in 2010.

Mahoney’s main area of research is investigating mechanisms that lead to improvements in nervous system function in the fruit fly model, Drosophila melanogaster. She is particularly interested in the effects of both age and the presence of neurological disorders, such as Alzheimer ’s disease, on synaptic function and finding novel mechanisms that lead to improvements in both in larval and adult preparations.

Mahoney is a member of the Society for Neuroscience and Genetic Society of America. She has published several papers in various high impact journals such as Aging CellElife and the Journal for Neuroscience.


Rawson JM, Kreko T, Davison H, Mahoney R, Bokov A, Chang L, Gelfond J, Macleod GT,Eaton BA (2012) Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease. Aging Cell Jun;11(3):418-27 PMCID: PMC3350605

Mahoney RE, Rawson JM and Eaton BA (2014) An age-dependent change in the synaptic homeostasis set point at the NMJ. J Neurosci 34(6): 2111-2119. PMCID: PMC3913865

Mahoney RE, Azpurua J, Eaton BA. Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery. Elife. 2016 Aug 15;5. pii: e16807. doi: 10.7554/eLife.16807. PMCID: PMC5012858

Kreko-Pierce T, Azpurua J, Mahoney RE, Eaton BA. Extension of Health Span and Life Span in Drosophila by S107 Requires the calstabin Homologue FK506-BP2 (2016) J Biol Chem. 2016 Nov 1. pii: jbc.M116.758839. PMCID: PMC5207075

Eaton BA and Mahoney RE (2017) Ciberial muscle 9 (CM9) electrophysiological recordings in Adult Drosophila melanogaster. Bio-protocol. 2017 DOI:10.21769/BioProtoc.2401

Azpurua J, Mahoney RE, Eaton BA (2018) Transcriptome profiling of Drosophila motor neurons uncovers age-dependent upregulation of a matrix proteinase that impairs motor function and survival. Aging Cell. 2018 Apr; 17(2): e12729 PMCID: PMC5847883

Mahoney RE and Frost B (2019) Pathogenic tau depletes CREB and nuclear Ca2+ through BK channel dysfunction (In prep)

Back to top